The History and Development of Sildenafil Citrate
Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking sildenafil.
| Brand Name | Manufacturer | Dose Forms | Price Range (approx.) |
|---|---|---|---|
| Viagra | Pfizer | 25 mg, 50 mg, 100 mg | $$$ |
| Sildenafil Citrate Teva | Teva Pharmaceuticals | 50 mg, 100 mg | Moderate |
| Caverta | Mankind Pharma | 50 mg, 100 mg | Affordable |
| Kamagra | Ajanta Pharma | 100 mg | Low-cost |
Do not start these medications while taking sildenafil without discussing it with your healthcare provider.
- Sildenafil citrate can be combined with lifestyle changes.
- Exercise and weight management improve erectile function.
- Quitting smoking enhances medication effectiveness.
- Reducing alcohol intake minimizes side effects.
- Psychological therapy may support ED treatment.
- Counseling can address underlying emotional issues.
- Regular medical check-ups are recommended.
- Patient education improves safe and effective use.
tell your doctor if you smoke, if you have had heart surgery within the last 6 months, if you have ever had
| Indication | Patient Group | Dosage Recommendation | Additional Notes |
|---|---|---|---|
| Erectile Dysfunction | Men aged 18-65 | 50 mg30-1 hour before activity | Adjust based on efficacy and tolerability |
| Pulmonary Hypertension | Adults with PAH | 20 mg three times daily | Extended release available |
| Raynaud's Phenomenon | People with secondary Raynaud's | Off-label use, consult physician | Limited clinical evidence |
an erection that lasted for more than 4 hours, and if you have recently lost a large amount of body fluids (dehydration).
2 Answers 2
This increased blood flow can cause an erection. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily. If you are taking sildenafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Sildenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). Sildenafil comes sildenafil oral jelly 100mg as a tablet and suspension (liquid) to take by mouth.
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If you are taking sildenafil to treat erectile dysfunction, follow your doctor's directions and the guidelines in this paragraph. Take sildenafil as needed before sexual activity. The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity. Sildenafil usually should not be taken more than once every 24 hours. If you have certain health conditions or are taking certain medications, your doctor may tell you to take sildenafil less often.
Sildenafil Tablets or Oral Suspension for PAH
You can take sildenafil with or without food. However, if you take sildenafil with a high-fat meal, it will take longer for the medication to start to work. If you are taking sildenafil to treat PAH, you will probably take sildenafil three times a day with or without food. Take sildenafil at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. This can happen if you are sick with fever, diarrhea, or vomiting; sweat a lot; or do not drink enough liquids.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 150mg | 20 Pills | 55.02€ 52.40€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Viagra Generic | 50mg | 360 + 10 Pills | 225.33€ 214.60€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Kamagra Polo | 100mg | 60 + 4 Pills | 189.39€ 180.37€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ | |
| Kamagra Polo | 100mg | 12 Pills | 60.21€ 57.34€ |
Also tell your doctor if you have or have ever had pulmonary
What special dietary instructions should I follow?
Make sure blue sildenafil you have discussed any other medications you are currently taking or plan to take before starting sildenafil with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking sildenafil, please get the advice of your doctor or pharmacist. tell your doctor if you are taking street drugs containing nitrates ('poppers') such as amyl nitrate, amyl nitrite, or butyl nitrate while taking sildenafil. Your doctor will tell you not to take sildenafil if you are taking street drugs containing nitrates. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. veno-occlusive disease (PVOD; blockage of veins in the lungs); a stomach ulcer; heart,
Viagra et environnement
Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well for 10 seconds before each use to mix the medication evenly. Use the oral syringe provided with your medication to measure and take your dose. Follow the manufacturer's directions to use and clean the oral syringe. Do not mix the liquid with other medications or add anything to flavor the medication.
Viagra Tablets
If you are taking sildenafil for erectile dysfunction, your doctor will probably start you on an average dose of sildenafil and increase or decrease your dose depending on your response to the medication. Tell your doctor if sildenafil is not working well or if you are experiencing side effects. If you are taking sildenafil for PAH, you should know that sildenafil controls PAH but does not cure it. Continue to take sildenafil even if you feel well. Do not stop taking sildenafil without talking to your doctor.
How is sildenafil supplied (dosage forms)?
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. tell your doctor and pharmacist if you are allergic to sildenafil, any other medications, or any of the ingredients in sildenafil tablet or suspension. Ask your pharmacist for a list of the ingredients. Some medications should not be taken with sildenafil. kidney, or liver disease; a heart attack; heart failure; angina (chest pain); an
What should I know about storage and disposal of this medication?
How should I store SILDENAFIL CITRATE TABLETS? Store SILDENAFIL CITRATE TABLETS at room temperature between 68°F to 77°F (20°C to 25°C). Keep SILDENAFIL CITRATE TABLETS and all medicines out of the reach of children. General information about the safe and effective use of SILDENAFIL CITRATE TABLETS. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet.
Revatio Injection
Do not use SILDENAFIL CITRATE TABLETS for a condition for which it was not prescribed. Do not give SILDENAFIL CITRATE TABLETS to other people, even if they have the same symptoms that you have. This Patient Information leaflet summarizes the most important information about SILDENAFIL CITRATE TABLETS. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about SILDENAFIL CITRATE TABLETS that is written for health professionals.
Effets indésirables
For more information, go to or call 1-800-438-1985 What are the ingredients in SILDENAFIL CITRATE TABLETS? This Patient Information has been approved by the U.S. Food and Drug Administration. This sildenafil citrate tablets 50 mg product's label may have been updated. For current full prescribing information, please visit Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc. irregular heartbeat; a stroke; chest pain; high or low blood pressure; high cholesterol;
Further information
The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc. The makers of these brands are not affiliated with and do not endorse Pfizer Inc or its products. SildenafilIn eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) 11,12,13,14,15,16,8,9. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid 11,12,13,14,15,16,8,9.Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late 1980s 7. Nevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary arterial hypertension but is also additionally notorious for interacting with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises 4,5,6.Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in the public in 1998 7, continues to see millions of prescriptions written for it internationally.
Related treatment guides
Although the medication has historically been most popularly recognized as Pfizer's brand name Viagra, sildenafil is currently available generically and even as a non-prescription over the counter medication in some countries 10. In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) 11,12,13,14,15,16,8,9. The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension and the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid 11,12,13,14,15,16,8,9. Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart - before being serendipitously indicated for treating erectile dysfunction in the late 1980s 7. Nevertheless, it is because of this mechanism that sildenafil is also indicated for treating pulmonary arterial hypertension but is also additionally notorious for interacting with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises 4,5,6.
Revatio Tablets
Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in the public in 1998 7, continues to see millions of prescriptions written for it internationally. Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Liqrev, Revatio) is used to improve the ability to exercise in adults (Liqrev, Revatio) and children 1 year of age and older (Revatio) with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. a bleeding disorder; blood circulation problems; blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the
Detection in biological fluids
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. you should know that sildenafil is available under the brand names Liqrev, Revatio, and Viagra. You should only be treated with one of these products at a time. The following nonprescription or herbal products may interact with sildenafil: cimetidine (Tagamet HB), St. John's wort. plasma cells), or leukemia (cancer of the white blood cells); conditions affecting the
- Sildenafil citrate’s patent expiration increased market competition.
- Generics help reduce treatment costs globally.
- Pharmaceutical companies conduct clinical trials regularly.
- Safety monitoring continues post-marketing.
- Adverse event reporting is essential for drug safety.
- Patients should only use approved formulations.
- Counterfeit sildenafil products are a concern.
- Purchase from reputable sources is advised.
shape of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie's disease); or diabetes.
| Side Effect | Frequency | Severity | Management Tips |
|---|---|---|---|
| Headache | Very common | Mild to moderate | Analgesics if needed |
| Flushing | Common | Mild | Cool environment, hydration |
| Dyspepsia | Common | Mild | Dietary adjustments |
| Nasal Congestion | Less common | Mild | Decongestants if necessary |
| Dizziness | Less common | Mild | Avoid sudden movements |